United travel to champions Manchester City in the Barclays Premier League on Saturday (5.30pm kick-off).
The Magpies go into the fixture on the back of a three-game unbeaten run which has seen a victory at Hull followed by two draws against Stoke and Crystal Palace.
The sides have already met twice this season. On the opening day, Manchester City ran out 2-0 winners.
However, United gained revenge a couple of months later when they beat the holders of the Capital One Cup 2-0, with Rolando Aarons and Moussa Sissoko on target.
Newcastle will be without Paul Dummett after he injured his knee cap in the 1-1 draw with Crystal Palace last time out and will likely be out for the rest of the season.
That means head coach John Carver heads to Manchester with captain Fabricio Coloccini, Mike Williamson, Daryl Janmaat and Massadio Haidara as his only fit senior defenders, while Remy Cabella (knee) is a doubt.
Nevertheless, Carver remains in confident mood and told his club’s official website: “We are going there knowing that we are playing against a good side, but we are not going to be fearful because we’ve proved that we can go there and get a result.”
Wilfried Bony will be available to make his long-awaited Manchester City debut. The Ivory Coast international striker Bony moved from Swansea City to the Etihad Stadium in January on the eve of embarking on a successful Africa Cup of Nations campaign with his country. Toure is also back and is expected to slot straight back into the starting line-up against Newcastle, while Bony will compete with Edin Dzeko and Stevan Jovetic for a place alongside top scorer Sergio Aguero as City boss Pellegrini has the pleasure of selecting from his full complement of attacking options.
Man City Hart, Zabaleta, Kompany (C), Mangala, Kolarov, Nasri, Fernandinho, Toure, Silva, Dzeko, Aguero
Subs Caballero, Demichelis, Clichy, Lampard, Fernando, Navas, Bony
Newcastle Utd Krul; Janmaat, Coloccini (c), Williamson, Haïdara; Sissoko, Anita, Colback; Pérez, Cissé, Gouffran.
Subs Woodman, R.Taylor, Abeid, Obertan, Ameobi, Armstrong, Rivière.